The popular painkiller
reduces empathy, study finds
Newswise, May 12, 2016 – When you take acetaminophen to reduce
your pain, you may also be decreasing your empathy for both the physical and
social aches that other people experience, a new study suggests.
Researchers at The Ohio State University found, for example,
that when participants who took acetaminophen learned about the misfortunes of
others, they thought these individuals experienced less pain and suffering,when
compared to those who took no painkiller.
“These findings suggest other people’s pain doesn’t seem as
big of a deal to you when you’ve taken acetaminophen,” said Dominik
Mischkowski, co-author of the study and a former Ph.D. student at Ohio State,
now at the National Institutes of Health.
“Acetaminophen can reduce empathy as well as serve as a
painkiller.”
Mischkowski conducted the study with Baldwin Way, who is an
assistant professor of psychology and member of the Ohio State Wexner Medical
Center’s Institute for Behavioral Medicine Research; and Jennifer Crocker, Ohio
Eminent Scholar in Social Psychology and professor of psychology at Ohio State.
Their results were published online in the journal Social Cognitive and
Affective Neuroscience.
Acetaminophen – the main ingredient in the painkiller Tylenol
– is the most common drug ingredient in the United States, found in more than
600 medicines, according to the Consumer Healthcare Products Association, a
trade group.
Each week about 23 percent of American adults (about 52
million people) use a medicine containing acetaminophen, the CHPA reports.
In an earlier study, Way and other colleagues found that
acetaminophen also blunts positive emotions like joy.
Taken together, the two studies suggest there’s a lot we need
to learn about one of the most popular over-the-counter drugs in the United
States.
“We don’t know why acetaminophen is having these effects, but
it is concerning,” said Way, the senior author of the study.
“Empathy is important. If you are having an argument with your
spouse and you just took acetaminophen, this research suggests you might be
less understanding of what you did to hurt your spouse’s feelings.”
The researchers conducted two experiments, the first involving
80 college students. At the beginning, half the students drank a liquid
containing 1,000 mg of acetaminophen, while the other half drank a placebo
solution that contained no drug.
The students didn’t know which group they were
in.
After waiting one hour for the drug to take effect, the
participants read eight short scenarios in which someone suffered some sort of
pain.
For example, one scenario was about a person who suffered a knife cut
that went down to the bone and another was about a person experiencing the
death of his father.
Participants rated the pain each person in the scenarios
experienced from 1 (no pain at all) to 5 (worst possible pain). They also rated
how much the protagonists in the scenarios felt hurt, wounded and pained.
Overall, the participants who took acetaminophen rated the
pain of the people in the scenarios to be less severe than did those who took
the placebo.
A second experiment involved 114 college students. As in the
first experiment, half took acetaminophen and half took the placebo.
In one part of the experiment, the participants received four
two-second blasts of white noise that ranged from 75 to 105 decibels. They then
rated the noise blasts on a scale of 1 (not unpleasant at all) to 10 (extremely
unpleasant).
They were then asked to imagine how much pain the same noise
blasts would cause in another anonymous study participant.
Results showed that, when compared to those who took the
placebo, participants who took acetaminophen rated the noise blasts as less
unpleasant for themselves – and also thought they would be less unpleasant for
others.
“Acetaminophen reduced the pain they felt, but it also reduced
their empathy for others who were experiencing the same noise blasts,”
Mischkowski said.
In another part of the experiment, participants met and
socialized with each other briefly.
Each participant then watched, alone, an
online game that purportedly involved three of the people they just met. (The
other participants weren’t actually involved).
In the “game,” two of the people the participants had met
excluded the third person from the activity.
Participants were then asked to rate how much pain and hurt
feelings the students in the game felt, including the one who was excluded.
Results showed that people who took acetaminophen rated the
pain and hurt feelings of the excluded student as being not as severe as did
the participants who took the placebo.
“In this case, the participants had the chance to empathize
with the suffering of someone who they thought was going through a socially
painful experience,” Way said.
“Still, those who took acetaminophen showed a reduction in
empathy. They weren’t as concerned about the rejected person’s hurt feelings.”
While these results had not been seen before, they make sense
in the light of previous research, Way said.
A 2004 study scanned the brains of people as they were
experiencing pain and while they were imagining other people feeling the same
pain. Those results showed that the same part of the brain was activated in
both cases.
“In light of those results, it is understandable why using Tylenol
to reduce your pain may also reduce your ability to feel other people’s pain as
well,” he said.
The researchers are continuing to study how acetaminophen may
affect people’s emotions and behavior, Way said. They are also beginning to
study another common pain reliever – ibuprofen – to see if it has similar
results.
The study was supported in part by a grant from the National
Center for Advancing Translational Sciences.
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